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suPAR

Independent data showing mechanism of suPAR damage to cells
Kim EY and Dryer SE., Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin, Cells 13, 172 (2024)

Mendelian Randomization demonstrates that suPAR causes renal disease
Hindy G, Tyrrell DJ, Vasbinder A, et al., Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis. J Clin Invest. Dec 15;132(24):e158788 (2022). See Figure S12 in supplementary data for association between suPAR, eGFR, and CKD

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis (FSGS)
Wei C, El Hindi S, Li J, et al., Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med 17, 952–960 (2011)

Association of suPAR levels with incident CKD and accelerated decline in eGRF
Hayek SS, Sever S, Ko YA, et al., Soluble urokinase receptor and chronic kidney disease. NEJM 373, 1916-1925 (2015)

suPAR fragment is toxic to islet cells and impacts late onset type 1 diabetes
Ke Z, Mukherjee K, Wei C, et al., The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. Sep 20;15(174):eabq6492 (2023)

What is the role of suPAR in evolution
Wei C, Datta PK, Siegerist F, et al., suPAR mediates viral response proteinuria by rapidly changing podocyte function. Nat Commun 14, 4414 (2023)

 

Dynamin

Key publication showing drugging of dynamin will have multiple beneficial outcomes on CKD from stimulating dynamin pathway
Schiffer M, Teng B, Gu C, et al., Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med 21(6):601–609 (2015)

Simultaneous activator treatment in two different kidney specific cells leads to improvements in crosslinking that preserves renal function
Mukherjee K, Gu C, Collins A, et al., Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun 13, 2422 (2022)

Role of dynamin in foot process formation and maintenance
Soda K, Balkin DM, Ferguson SM, et al., Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest. 122(12):4401–4411 (2012)

CD2AP is gatekeeper of podocyte TGF-β1 response. Genetic lesions in CD2AP leads to renal failure
Yaddanapudi S, Altintas MM, Kistler AD, et al., CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest 121(10):3965-3980 (2011)